900: Adrenomedullin2 (ADM2) receptor system in placenta from preeclamptic pregnancy

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Complement Activation and Regulation in Preeclamptic Placenta

Preeclampsia (PE) is a common disorder of pregnancy originating in the placenta. We examined whether excessive activation or poor regulation of the complement system at the maternal-fetal interface could contribute to the development of PE. Location and occurrence of complement components and regulators in placentae were analyzed. Cryostat sections of placentae were processed from 7 early-onset...

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Adrenomedullin2 Antagonist Alters Fetoplacental Growth Rate during Rat Late Gestation

Adrenomedullin-2 (ADM2), a novel calcitonin/calcitonin-gene related peptide family with an exon-intron structure similar to that of ADM. The aim of the present study is to evaluate the role of Adrenomedullin-2 (ADM2) on fetoplacental development in female pregnant albino rats and to evaluate the effect of adrenomedullin2 antagonist (ADM21747) on fetal and placental development in late gestation...

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Umbilical Cord Blood Changes in Neonates from a Preeclamptic Pregnancy

During pregnancy, mother's well-being affects directly the newborn development. Some maternal and placental complications, such as gestational diabetes, preeclampsia (PE), preterm delivery and intrauterine growth restriction (IUGR), may contribute to fetal growth deviations or fetal development modifications. Usually the newborn weight correlates positively with placenta weight, showing the int...

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Glomerular ultrafiltration in normal and preeclamptic pregnancy.

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Landscape of Transcriptional Deregulations in the Preeclamptic Placenta

Preeclampsia is a pregnancy disease affecting 5 to 8% of pregnant women and a leading cause of both maternal and fetal mortality and morbidity. Because of a default in the process of implantation, the placenta of preeclamptic women undergoes insufficient vascularization. This results in placental ischemia, inflammation and subsequent release of placental debris and vasoactive factors in the mat...

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ژورنال

عنوان ژورنال: American Journal of Obstetrics and Gynecology

سال: 2017

ISSN: 0002-9378

DOI: 10.1016/j.ajog.2016.11.809